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Intellectual Capital ::

Torrent believes that its human capital in the basis of its development. Torrent R&D Centre, begun by few scientists, is today manned by over 600 scientists with a combined experience of over 3000 scientific man-years in Drug Discovery and Development.

Today, our R&D Centre has transformed into a training ground for many new young scientists. Its rich human capital coupled with high-tech equipments gives it a cutting edge in the field of research and development. Efforts are on to provide scientists with opportunities to develop their capabilities further through training.

Select Patents:

1. (US6624178) Compounds for the management of aging-related and diabetic vascular complications, process for their preparation and therapeutic uses thereof
2. (US6608094) Compounds for the management of aging-related and diabetic vascular complications, process for their preparation and therapeutic uses thereof
3. (US 6462057) Compounds for the management of aging-related and diabetic vascular complications, process for their preparation and therapeutic uses thereof
4. (US7223777) Compounds for the management of aging-related and diabetic vascular complications, process for their preparation and therapeutic and cosmetic uses thereof
5. (WO/2008/149379) Novel compounds


Select Publications:

1. TRC150094 attenuates progression of nontraditional cardiovascular risk factors associated with obesity and type 2 diabetes in obese ZSF1 rats; Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy; January 2011 , Volume 2011:4, Pages 5 - 16; Shitalkumar P Zambad, Siralee Munshi, Amita Dubey, Ram Gupta, Rosa Anna Busiello, Antonia Lanni, Fernando Goglia, Ramesh C Gupta, Vijay Chauthaiwale, Chaitanya Dutt.
2. TRC150094, a novel functional analog of iodothyronines, reduces adiposity by increasing energy expenditure and fatty acid oxidation in rats receiving a high-fat diet; FASEB J 2010 May 7 [Epub ahead of print]; Federica Cioffi, Shitalkumar P. Zambad, Laxmikant Chhipa, Rosalba Senese, Rosa Anna Busiello, Davinder Tuli, Siralee Munshi, Maria Moreno, Assunta Lombardi, Ramesh C. Gupta, Vijay Chauthaiwale, Chaitanya Dutt, Pieter de Lange, Elena Silvestri, Antonia Lanni and Fernando Goglia.
3. TRC4186, a Novel AGE-breaker, Improves Diabetic Cardiomyopathy and Nephropathy in Ob-ZSF1 Model of Type 2 Diabetes; Journal of Cardiovascular Pharmacology: July 2009; 54:72-81; Joshi, Deepa; Gupta, Ram; Dubey, Amita; Shiwalkar, Ajay; Pathak, Padmaja; Gupta, Ramesh C; Chauthaiwale, Vijay; Dutt, Chaitanya
4. Phase I clinical studies of the advanced glycation end-product (AGE)-breaker TRC4186: safety, tolerability and pharmacokinetics in healthy subjects; Clin Drug Investig. 2009;29(9):559-75; Chandra KP, Shiwalkar A, Kotecha J, Thakkar P, Srivastava A, Chauthaiwale V, Sharma SK, Cross MR, Dutt C
5. Continuous, non-invasive measurement of the haemodynamic response to submaximal exercise in patients with diabetes mellitus. Evidence of impaired cardiac reserve and peripheral vascular response; Heart 2010 Jan; 96(1):36-41; Deepa Joshi, Ajay Shiwalkar, Maurice Cross, Sanjay Sharma, Ashish Vachhani, Chaitanya Dutt
6. TRC4149 a novel advanced glycation end product breaker improves hemodynamic status in diabetic spontaneously hypertensive rats; European Journal of Medical Research, 2008;13(8):388-398; Pathak P, Gupta R, Chaudhari A, Shiwalkar A, Dubey A, Mandhare AB, Gupta RC, Joshi D, Chauthaiwale V.
7. Synthesis of spiro[chroman-2,4'-piperidin]-4-one derivatives as acetyl-CoA carboxylase inhibitors; Bioorganic & Medicinal Chemistry Letters, 2009 Feb 1;19(3):949-53. Epub 2008 Dec 3; Shinde P, Srivastava SK, Odedara R, Tuli D, Munshi S, Patel J, Zambad SP, Sonawane R, Gupta RC, Chauthaiwale V, Dutt C.

8.

Novel N-substituted 4-hydrazino piperidine derivative as a dipeptidyl peptidase IV inhibitor; Bioorganic & Medicinal Chemistry Letters, 2009 Sep 1;19(17):5021-5. Epub 2009 Jul 12; Gupta RC, Chhipa L, Mandhare AB, Zambad SP, Chauthaiwale V, Nadkarni SS, Dutt C.

9.

Delayed intervention in experimental stroke with TRC051384 - A small molecule HSP70 inducer; Neuropharmacology, 2011 May; 60(6):991-9. Epub 2010 Dec 16; Mohanan A, Deshpande S, Jamadarkhana PG, Kumar P, Gupta RC, Chauthaiwale V, Dutt C.

 

 
 

 

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